FUNDAMENTAL QUESTIONS

Persistent subjective states of anxiety or depression resulting from chronic stress, pain, or incidence of trauma, facilitate dynamic and iterative dysregulation across sensory-motor, emotional, and cognitive processes. These chronic maladaptive states increase the likelihood of poor health outcomes including immunodeficiency, inflammation, and psychopathology. Fortunately, a growing body of research suggests that certain forms of systematic mental training associated with mindfulness-based meditation and other wisdom-based contemplative practices can provide the requisite tools for improved self-awareness, self-regulation, prosocial behavior, and overall well-being. 

Based on these observations, there are three main questions that drive my program of contemplative neuroscience research and inquiry: 

  • Through mixed research methods of systems biology, neuroimaging, predictive computational modeling, connectomics, genomic and neuroendocrine science, innovation, cognitive-behavioral and first-person phenomenological analyses,  can we identify the basic neuro-psycho-social mechanisms that contribute to adaptive mind-brain-body interactions and their therapeutic relevance in health settings?
  • What are the basic developmental patterns of body-mind-brain changes that result from rigorous mental training in contemplative practices and establish the development of a flourishing constitution?
  • How can innovation and technology, through biosensor, stimulation, psycholytic and psychedelic pharmacology, serve to enhance or augment mental health and well-being?

MAPPING THE MEDITATIVE MIND (M3)

Diagnostics, Navigation, Prediction, and Mechanism

Mechanisms of MBIs (MOMBI Trial)

What are the Neurobiological Markers by which MBI’s improve clinical outcomes?

Acupuncture for Acute Pain

Low-cost Alternatives to Opiates in the ED

Targeting & Validating Attention Regulation Markers of Mindfulness for Pain

Neural Markers for Predicting Pain Outcomes

Imaging Inflammatory Markers

Targeting brain-based markers of inflammation sensitive to meditation